Systems glycobiology enabled by innovations in mass spectrometry and chemical biology

Glycosylation is a dominant feature of extracellular phenotypes. Glycoproteins present distinct combinations of glycans and amino acids that create unique molecular surfaces to relay biological information in a language called the glycocode. Despite evidence that the glycocode orchestrates numerous aspects of cell surface biology, we lack a fundamental understanding of the glycosylation landscape across the proteome, largely because we do not have tools to capture the glycocode at a systems level. Our group works to address this critical gap in current analytical technology to study glycocode regulation across biological networks that govern health and disease.

Latest News

2024.04.19

Our review on Instrumentation at the Leading Edge of Proteomics

is accepted by Analytical Chemistry! Check out the pre-print

version at ChemRxiv. Congrats all!


2024.04.11 thru 2024.04.14

Nick attends the Scialog Conference on Automating

Chemical Laboratories as a Scialog Fellow.


2024.04.02

Collaborative work involving the Riley Research Group

and led by the Polyak group at Harvard Medical School

is accepted for publication in PNAS. Congrats all!


2024.03.25

The Spring Quarter 2024 begins! Nick is teaching

CHEM 428/528 Biomolecular Analysis and

CHEM 196 Chemistry Frontiers.


2024.03.22

ASMS announces that Nick is one of the

recipients of the 2024 Research Awards!



2024.03.10 thru 2024.03.13

Nick and Emmajay attend US HUPO 2024 in Portland, OR. Nick presents at the workshop

on Creativity in Scientific Communication during Early Career Researcher Mentoring Day 

and gives a talk in the Functional Characterization of the Proteome parallel session.

Emmajay does an awesome job presenting a lightning talk and her poster.

She even won an Honorable Mention in the lightning talk competition!


2024.03.01

The second 2024 UW Chemistry Graduate Student Open House kicks off!

We are excited to meet and interact with everyone.


2024.02.23 thru 2024.02.25

The Riley Research Group attends the 2024 Volcano Conference.

Tim and Emmajay give great talks, and we enjoy meeting other UW

and PNW chemical biologists!


2024.02.16

The first 2024 UW Chemistry Graduate Student Open House kicks off!

We are looking forward to meeting and interacting with everyone.


2024.01.03

The Winter Quarter 2024 begins! Nick is teaching

CHEM 321, Quantitative Analysis.


2024.01.02

Nick joins as a new provisional faculty member of UW's

Molecular and Cellular Biology (MCB) Graduate Program!


2023.12.22

We welcome new first-year graduate students Anna Duboff, Katie Kothlow,

Kayla Markuson, Jacob Russell, and Ruby Zhang to the group.

We are excited to have each of you join the group

and look forward to the fun science ahead!



See News and Updates for more!


Our Philosophy

We are a lab committed to quality science and a supportive lab environment. Collaboration and mentorship are themes of our group,

and we aim to make sure everyone has the opportunity to pursue their goals in research and beyond.