Systems glycobiology enabled by innovations in mass spectrometry and chemical biology

Glycosylation is a dominant feature of extracellular phenotypes. Glycoproteins present distinct combinations of glycans and amino acids that create unique molecular surfaces to relay biological information in a language called the glycocode. Despite evidence that the glycocode orchestrates numerous aspects of cell surface biology, we lack a fundamental understanding of the glycosylation landscape across the proteome, largely because we do not have tools to capture the glycocode at a systems level. Our group works to address this critical gap in current analytical technology to study glycocode regulation across biological networks that govern health and disease.

Latest News


2024.07.23

Katie wins first place for her poster at Cascadia 

Proteomics Symposium 2024! Congrats, Katie!


2024.07.23

Jacob and Nick give talks, and Haley gives a flash talk at 

Cascadia Proteomics Symposium 2024!


2024.07.22

Daniel gives a talk and Katie gives a flash talk at Cascadia 

Proteomics Symposium 2024!


2024.07.22 thru 2024.07.23

RRG attends Cascadia Proteomics Symposium 2024 

at the Institute for Systems Biology in SLU.


2024.07.01

Anna receives the Member-at-Large Educational Reentry Award given by

the National Honor Society for Women in Chemistry. Congrats, Anna!


2024.06.26

Daniel attends FASEB conference in Southbridge, MA and 

presents a talk on KRAS phosphorylation that drives cell invasiveness.


2024.06.20

Research Intern Vishnu Rajan joins us for a

internship experience. Welcome, Vishnu!


2024.06.17

Undergraduate student Adrian Tarroza joins us for a 

summer internship through SCROCCS. Welcome, Adrian!


2024.06.11

Graduate student Daniel Gómez Zepeda joins us for a 

summer internship. Welcome, Daniel!


2024.06.11

Dr. Haley Schramm begins her first day as a postdoc in the group.

She finished her Ph.D. in Chemistry with Prof. Brian Clowers at Washington 

State University. Welcome, Haley! We are excited to have you here!


2024.06.07

The South Carolina Honors colleges publishes a piece titled

"Investigating the Interfaces" that highlights Nick as the SCHC

2023 Distinguished Young Honors Alumni awardee.


2024.06.06

Kayla, Jacob, Anna, and Katie present their posters in the

Glycoproteins II session at ASMS 2024. They also did a great job!


2024.06.05

Ruby, Emmajay, and Tim present their posters in the

Glycoproteins I session at ASMS 2024. They did a great job!


2024.06.04

Nick receives the ASMS Research Award during the

Tuesday Award ceremony at ASMS.


2024.06.03

Nick presents a talk in the Glycopeptides, Glycoproteins,

and Glycomics session at ASMS 2024 in Anaheim.


2024.06.01

The RRG travels to Anaheim for ASMS 2024 and makes

a Saturday pitstop at Disneyland before the conference begins!


2024.05.30

Nick presents at the Quantitative Biosciences Institute-Rezo Therapeutics

Mass Spectrometry Symposium on Emerging Proteomic Technologies

to Address Outstanding Biological Challenges.


2024.05.28

Nick is interviewed by LCGC International Magazine

to highlight his upcoming ASMS 2024 talk.


2024.05.13

Our first publication as a group, a review titled "Instrumentation

at the Leading Edge of Proteomics", is published in Analytical Chemistry!


2024.05.07

Emmajay, Tim, and Nick present as the featured speakers

 at the PacMass Spring 2024 meeting.


2024.04.26

Nick visits the Complex Carhohydrate Research Center

and UGA's Department of Biochemistry and Molecular Biology

to present a seminar.


2024.04.19

Our review on Instrumentation at the Leading Edge of Proteomics

is accepted by Analytical Chemistry! Check out the pre-print

version at ChemRxiv. Congrats all!


2024.04.11 thru 2024.04.14

Nick attends the Scialog Conference on Automating

Chemical Laboratories as a Scialog Fellow.


2024.04.02

Collaborative work involving the Riley Research Group

and led by the Polyak group at Harvard Medical School

is accepted for publication in PNAS. Congrats all!


2024.03.25

The Spring Quarter 2024 begins! Nick is teaching

CHEM 428/528 Biomolecular Analysis and

CHEM 196 Chemistry Frontiers.


2024.03.22

ASMS announces that Nick is one of the

recipients of the 2024 Research Awards!



2024.03.10 thru 2024.03.13

Nick and Emmajay attend US HUPO 2024 in Portland, OR. Nick presents at the workshop

on Creativity in Scientific Communication during Early Career Researcher Mentoring Day 

and gives a talk in the Functional Characterization of the Proteome parallel session.

Emmajay does an awesome job presenting a lightning talk and her poster.

She even won an Honorable Mention in the lightning talk competition!




See News and Updates for more!


Our Philosophy

We are a lab committed to quality science and a supportive lab environment. Collaboration and mentorship are themes of our group,

and we aim to make sure everyone has the opportunity to pursue their goals in research and beyond.